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Drostanolone Propionate steroids for sale at online anabolic pharmacy. Buy Masteron online at cheap prices for cutting cycles. Mastodex injectable anabolic Although one must be cautious in comparing one-year data to three–year data, there clearly was no dramatic rise in prostate cancers in this highrisk group receiving TRT. Longitudinal studies of endogenous T levels and prostate cancer risk Longitudinal studies with frozen sera represent one of the more powerful types of studies to investigate the potential etiologic effect of hormone levels on subsequent development of a disease such as prostate cancer. At least 12 such longitudinal population-based studies have been performed looking at the relationship of endogenous T levels (as well as other hormones) to prostate cancer, involving tens of thousands of men. At the end of the study, a cohort had developed prostate cancer, and the remainder did not. Blood samples from these men from years earlier were then compared to see whether testosterone levels differed between these two groups. Not one of the twelve studies demonstrated a difference in T levels between men who did and did not develop cancer.

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Unlike orally administered alkylated androgen preparations, testosterone is aromatized to estrogen. In men with hypogonadism treated with replacement doses of testosterone, total cholesterol and LDL levels may modestly decrease in conjunction with minimal change in HDL thus, investigators have speculated that the risk of cardiovascular disease may be higher in men with hypogonadism not receiving testosterone replacement (45). Testosterone replacement therapy in men is not associated with major adverse lipid changes (46) in fact, endogenous testosterone and administration of exogenous testosterone may lower the atherogenic Lp(a) lipoprotein levels (47). Other studies suggest that testosterone replacement in men with hypogonadism may be associated with adverse lipid effects, and yet other studies have reported indeterminate findings (27). Other cardiovascular effects apart from changes in lipids may be attributable to testosterone replacement therapy. A potential risk of testosterone therapy is the propensity of testosterone to increase platelet aggregation and thrombogenicity (48). Currently, whether testosterone replacement therapy in men with hypogonadism increases, decreases, or has a neutral effect on cardiovascular risk remains uncertain.

 

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